Will the nanotech poison work right once it's in Gio's body? It could get disrupted too, if you wanted ahaha But those symptoms sound like A BUCKET OF FUN all on their own, and Hijikata would work to restrain him and dampen whatever unnecessary side effects he can.

oh no don't put down the doggo - I'd love for them to have that conversation, at least, even if Hijikata decides to report it (and may mention that there are other reports of this - he'd look into it - to comfort Gio)